"The 'RNA world' scenario hinges on some rather far-fetched assumptions about the catalytic ability of RNA. For example, RNA polymerase ribozymes must have been responsible for replicating the ribozymes of the RNA world, including themselves (via their complementary sequences). RNA replication is a very challenging set of reactions -- far more challenging than those yet known to be catalyzed by RNA."
Bartle, David P. and Unrau, Peter J.
"Constructing an RNA World"
Trends in Biochemical Sciences 24 (1999): M9-M13.
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