The type III secretion system (T3SS) has risen from comparative obscurity to become the focus of attention for many researchers. This is partly because if its potential for medical applications, and partly because it has the distinction of being constructed from a subset of components found in the bacterial flagellum. Some have advanced the view that the T3SS is a link in the gradualist chain leading to the formation of the bacterial flagellum, thereby disproving the claim by Michael Behe that this structure is irreducibly complex. New research is far from confirming the gradualist hypothesis. The “T3SSs are among the most complex protein secretion systems known in bacteria.” In a recent review of what is known of their structure, the authors write: “We have focused on what we believe are the general principles that govern the function of these biological machines.....” Just as the bacterial flagellum is an exquisite nano-machine, so also is the T3SS a striking example of nanotechnology. Whilst it may be possible to interpret T3SS as derived from the more complex flagellum, the route to gradual construction of these structures is as far off as ever.
Protein delivery into eukaryotic cells by type III secretion machines
Jorge E. Galán and Hans Wolf-Watz
Nature 444, 567-573 (30 November 2006) | doi:10.1038/nature05272
Abstract: Bacteria that have sustained long-standing close associations with eukaryotic hosts have evolved specific adaptations to survive and replicate in this environment. Perhaps one of the most remarkable of those adaptations is the type III secretion system (T3SS)—a bacterial organelle that has specifically evolved to deliver bacterial proteins into eukaryotic cells. Although originally identified in a handful of pathogenic bacteria, T3SSs are encoded by a large number of bacterial species that are symbiotic or pathogenic for humans, other animals including insects or nematodes, and plants. The study of these systems is leading to unique insights into not only organelle assembly and protein secretion but also mechanisms of symbiosis and pathogenesis.
|<< <||> >>|
Evolution has become a favorite topic of the news media recently, but for some reason, they never seem to get the story straight. The staff at Discovery Institute's Center for Science and Culture started this Blog to set the record straight and make sure you knew "the rest of the story".
A blogger from New England offers his intelligent reasoning.
We are a group of individuals, coming from diverse backgrounds and not speaking for any organization, who have found common ground around teleological concepts, including intelligent design. We think these concepts have real potential to generate insights about our reality that are being drowned out by political advocacy from both sides. We hope this blog will provide a small voice that helps rectify this situation.
Website dedicated to comparing scenes from the "Inherit the Wind" movie with factual information from actual Scopes Trial. View 37 clips from the movie and decide for yourself if this movie is more fact or fiction.
Don Cicchetti blogs on: Culture, Music, Faith, Intelligent Design, Guitar, Audio
Australian biologist Stephen E. Jones maintains one of the best origins "quote" databases around. He is meticulous about accuracy and working from original sources.
Most guys going through midlife crisis buy a convertible. Austrialian Stephen E. Jones went back to college to get a biology degree and is now a proponent of ID and common ancestry.
Complete zipped downloadable pdf copy of David Stove's devastating, and yet hard-to-find, critique of neo-Darwinism entitled "Darwinian Fairytales"
Intelligent Design The Future is a multiple contributor weblog whose participants include the nation's leading design scientists and theorists: biochemist Michael Behe, mathematician William Dembski, astronomer Guillermo Gonzalez, philosophers of science Stephen Meyer, and Jay Richards, philosopher of biology Paul Nelson, molecular biologist Jonathan Wells, and science writer Jonathan Witt. Posts will focus primarily on the intellectual issues at stake in the debate over intelligent design, rather than its implications for education or public policy.
A Philosopher's Journey: Political and cultural reflections of John Mark N. Reynolds. Dr. Reynolds is Director of the Torrey Honors Institute at