Science Literature
Post details: New paper on the bacterial flagellum from the Design and Nature II Conference
10/19/04
New paper on the bacterial flagellum from the Design and Nature II Conference
Genetic Analysis of Coordinate Flagellar and Type III Regulatory Circuits in Pathogenic Bacteria
By: Scott A. Minnich & Stephen C. Meyer
Second International Conference on Design & Nature, Rhodes Greece. Comparing Design in Nature with Science and Engineering
September 1, 2004
Abstract
The bacterial flagellum represents one of the best understood molecular machines. Comprised of 40 parts that self-assemble into a true rotary engine, the biochemistry and genetics of these systems has revealed an unanticipated complexity. An essential component to assembly is the subset of parts that function as a protein secretory pump to ensure and discriminate that the correct number of protein subunits and their order of secretion is precisely regulated during assembly. Of further interest is the recognition of late that a number of important plant and animal pathogens use a related protein secretory pump fused to a membrane-spanning needle-like syringe by which a subset of toxins can be injected into target host cells. Together, the flagellar and virulence protein pumps are referred to as Type III Secretion Systems (TTSS). The archetype for TTSS systems has been the pathogenic members of the genus Yersinia which includes the organism responsible for bubonic plague, Y. pestis. Our interest in the Yersinia centers on the coordinate genetic regulation between flagellum biosynthesis and virulence TTSS expression. Y. enterocolitica, for example operates three TTSSs (motility, Ysa, and Yop), but each is expressed under defined mutually exclusive conditions. Y. pestis has lost the ability to assemble flagella (the genes are present on the chromosome) and expresses only the Yop system at 37oC, mammalian temperature. Using a combination of microarray analysis, genetic fusions, and behaviors of specific engineered mutants, we demonstrate how environmental factors influence gene expression of these multigene families, where the influence is exerted within each system, and propose why segregating these systems is critical for the organism. Our model further offers an explanation as to why an important subset of human pathogens has lost motility during their histories.
Science Literature
| Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|
| << < | > >> | |||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| 15 | 16 | 17 | 18 | 19 | 20 | 21 |
| 22 | 23 | 24 | 25 | 26 | 27 | 28 |
| 29 | 30 | 31 | ||||
Search
Categories
Archives
- March 2010 (4)
- February 2010 (6)
- January 2010 (6)
- December 2009 (5)
- November 2009 (6)
- October 2009 (5)
- September 2009 (6)
- August 2009 (4)
- July 2009 (12)
- June 2009 (6)
- May 2009 (5)
- April 2009 (9)
- more...
Linkblog
Links - Groups and Organizations
- Access Research Network
- Discovery Institute
- Evolution News Blog
Evolution has become a favorite topic of the news media recently, but for some reason, they never seem to get the story straight. The staff at Discovery Institute's Center for Science and Culture started this Blog to set the record straight and make sure you knew "the rest of the story".
- Intelligent Design Network (IDNet)
- Intelligent Design Undergraduate Research Center
- Intelligent Reasoning
A blogger from New England offers his intelligent reasoning.
- International Society for Complexity, Information, and Design (ISCID)
- Telic Thoughts
We are a group of individuals, coming from diverse backgrounds and not speaking for any organization, who have found common ground around teleological concepts, including intelligent design. We think these concepts have real potential to generate insights about our reality that are being drowned out by political advocacy from both sides. We hope this blog will provide a small voice that helps rectify this situation.
- The Design Inference - The Writings of William A. Dembski
- The Intelligent Design and Evolution Awareness Center (IDEA)
- www.themonkeytrial.com
Website dedicated to comparing scenes from the "Inherit the Wind" movie with factual information from actual Scopes Trial. View 37 clips from the movie and decide for yourself if this movie is more fact or fiction.
Links - Of General Interest
- A Brief View of Time and Those That Live There
Don Cicchetti blogs on: Culture, Music, Faith, Intelligent Design, Guitar, Audio
- A Quick Guide to Sequenced Genomes
- ARN Related Web Links
- Creation/Evolution Quotes
Australian biologist Stephen E. Jones maintains one of the best origins "quote" databases around. He is meticulous about accuracy and working from original sources.
- CreationEvolutionDesign
Most guys going through midlife crisis buy a convertible. Austrialian Stephen E. Jones went back to college to get a biology degree and is now a proponent of ID and common ancestry.
- Darwinian Fairytales by David Stove
Complete zipped downloadable pdf copy of David Stove's devastating, and yet hard-to-find, critique of neo-Darwinism entitled "Darwinian Fairytales"
- ID The Future
Intelligent Design The Future is a multiple contributor weblog whose participants include the nation's leading design scientists and theorists: biochemist Michael Behe, mathematician William Dembski, astronomer Guillermo Gonzalez, philosophers of science Stephen Meyer, and Jay Richards, philosopher of biology Paul Nelson, molecular biologist Jonathan Wells, and science writer Jonathan Witt. Posts will focus primarily on the intellectual issues at stake in the debate over intelligent design, rather than its implications for education or public policy.
- John Mark Reynolds Blog
A Philosopher's Journey: Political and cultural reflections of John Mark N. Reynolds. Dr. Reynolds is Director of the Torrey Honors Institute at
Biola University.
- NASA Astronomy Picture of the Day
Misc
Syndicate this blog 
What is RSS?
powered by
Original template design by François PLANQUE.
