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Post details: Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements
08/30/10
Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements
This is very technical, but the research shows that the randomness of Darwinism should be seriously questioned.
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From the Oxford Journal...
"Throughout evolution, eukaryotic genomes have been invaded by transposable elements (TEs). Little is known (emphasis mine) about the factors leading to genomic proliferation of TEs, their preferred integration sites and the molecular mechanisms underlying their insertion. We analyzed hundreds of thousands of nested TEs in the genome, i.e. insertions of TEs into existing ones. We first discovered that most TEs insert within specific 'hotspots' along the targeted TE. In particular, retrotransposed Alu elements contain a non-canonical single nucleotide hotspot for insertion of other Alu sequences. We next devised a method for identification of integration sequence motifs of inserted TEs that are conserved within the targeted TEs. This method revealed novel sequences motifs characterizing insertions of various important TE families: Alu, hAT, ERV1 and MaLR. Finally, we performed a global assessment to determine the extent to which young TEs tend to nest within older transposed elements and identified a 4-fold higher tendency of TEs to isnert into existing TEs than to insert within non-TE intergenic regions. Our analysis demonstrates that TEs are highly biased to insert within certain TEs, in specific orientations and within specific targeted TE positions. TE nesting events also reveal new characteristics of the molecular mechanisms underlying transposition."
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These are not isolated results...such as the identical exon substitutions in the GULO pseudogene in humans, chimpanzee and the guinea pig and the linear pattern of placement of retroviral elements among mice and rats.
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