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Post details: Analysis Reveals Extent of DNA Repair Army
05/25/07
Analysis Reveals Extent of DNA Repair Army
Cells have the remarkable ability to keep track of their genetic contents and - when things go wrong - to step in and repair the damage before cancer or another life-threatening condition develops.
But precisely how cells monitor the integrity of their genomes, identify problems, and intervene to repair broken or miscoded DNA has been one of nature's closely held secrets. Now, however, a report in the journal Science describes a new database developed by a team of researchers from the Howard Hughes Medical Institute at Harvard Medical School that is providing the first detailed portrait of the army of more than 700 proteins that helps maintain DNA's integrity.
How this complex system could have appeared by random mutation and natural selection is mind-numbing.
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