Archives for: May 2006, 19

05/19/06

Permalinkby 09:00:53 pm, Categories: Science, Life Sciences, 152 words   English (US)

Systems approach yields new information about DNA repair mechanism

A top-down systems approach to biology is yeilding new information about the complexity of the DNA repair mechanism.

Many cellular processes -- including DNA replication and repair, cell cycle control, metabolism, and stress responses -- form an integrated response to DNA damage, according to a report in this week's Science. The authors used a systems biology approach to create a map of transcriptional networks that are activated when yeast DNA is damaged.

"We now know an order of magnitude more pathway connections than were known before, as far as how information is transmitted through the cell in response to damage," senior author Trey Ideker of the University of California, San Diego, told The Scientist. Looking at cellular processes from a wide-angle view -- rather than the one-gene, one-protein approach of classical biology -- permits the construction of "a complete wiring diagram" of transcriptional interactions, Ideker said, which will help scientists control cellular response to DNA damage.

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